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1. (Article ID: 11465)
 
Kim HJ, Woo ER, Shin CG, Park H
A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase
Journal of Natural Products 61(1) (1998) 145-148
 

Bioassay-directed chromatographic fractionation of an ethyl acetate extract of the leaves of Acer okamotoanum using HIV-1 integrase afforded a new acylated flavonol glycoside, quercetin 3-0-(2 ",6 "-0-digalloyl)-beta-D-galactopyra (1), together with six known flavonol glycosides and three known phenolic compounds. The structure of the new compound was determined by spectroscopic methods. The most active compounds were quercetin 3-O-(2 "-galloyl)-alpha-L-arabinopyranoside (6) and 1, which exhibited IC50 values of 18.1 +/- 1.3 and 24.2 +/- 6.6 mu g/mL, respectively, against HIV-1 integrase.

iridoid glucosides, secoiridoid glucosides, loganic acid, loganin, Loasa acerifolia, Loasaceae, acerifolioside, tricoloroside methyl ester

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