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1. (Article ID: 11487)
 
Matsuda H, Ishikado A, Nishida N, Ninomiya K, Fujiwara H, Kobayashi Y, Yoshikawa M
Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica
Bioorganic and Medicinal Chemistry Letters 8(21) (1998) 2939-2944
 

The 50% aqueous methanolic extract from the bark of Betula platyphylla SUKATCHEV var. japonica (MIQ) HARA was found to show potent inhibitory activity on the liver-injury induced by CCl4 or D-galactosamine (D- GalN)/lipopolysaccharide as well as O2- scavenging and antioxidative activities. From the 50% aqueous methanolic extract, two new diarylheptanoids named betulaplatosides Ia (1) and Ib (2) and a new arylbutanoid named betulaplatoside II (3) were isolated together with seventeen known aromatic constituents. 1, 2, and two known diarylheptanoids [(5S)-5-hydroxy-1,7-bis- (4-hydroxyphenyl)-3-heptanone 5-O-β-D-apiofurano-syl-(1→6)-β-D- glucopyranoside (6) and aceroside VIII (7)] showed protective activity against D-GaIN-induced cytotoxicity in primary cultured rat hepatocytes. Furthermore, several aromatic constituents exhibited potent O2- scavenging and antioxidative activities.

mice, Animals, Plant Extracts, Antioxidants, free radical scavengers, liver, Betula platyphylla, Betula

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