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1. (Article ID: 11548)
Jung D, Sung C
Production of antibody against saikosaponin a, an active component of bupleuri radix
Archives of Pharmacal Research 21(2) (1998)
135-139
High titer rabbit polyclonal antibodies (pAbs) which show a specificity for saikosaponin a (SSA), have been generated. The immunogen used was a conjugate of SSA linked through its glucose moiety to bovine serum albumin by periodate oxidation method. The antibody titers obtained from two rabbits, innoculated with the immunogen, reached a plateau after the fourth and third booster injection, respectively. The specificity of the pAbs was determined by hapten inhibition assays using several SSA-like structures. SSA competitively inhibited the binding of the rabbit anti-SSA pAbs to SSA-ovalbumin on solid phase, a coated antigen on the well. The antibodies showed high specificity to SSA, exhibiting no significant cross-reactivity with any of SSA analogues tested.
Periodate oxidation, polyclonal antibodies, saikosaponin a, Hapten inhibition assay
NCBI PubMed ID: 9875420Publication DOI: 10.1007/BF02974017Journal NLM ID: 8000036Publisher: Pharmaceutical Society of Korea
Institutions: College of Pharmacy, Chonnam National University, Kwangju, South Korea
Methods: 13C NMR, 1H NMR, biological assays, extraction, Hapten inhibition test
The publication contains the following compound(s):
- Compound ID: 23791
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b-D-Glcp-(1-3)-b-D-Fucp-(1-3)-Subst
Subst = saikogenin F = SMILES C[C@@]1({23}CO){3}[C@@H](O)CC[C@]2(C)[C@@]3([H])C=C[C@]45[C@]6([H])CC(C)(C)CC[C@@](CO5)6{16}[C@@H](O)C[C@](C)4[C@@](C)3CC[C@@]12[H] |
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Structure type: oligomer
Trivial name: saikosaponin a, saikosaponin-a
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
Reference(s) to other database(s): CCSD:
27760, CBank-STR:3093
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