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1. (Article ID: 11762)
Ramesh M, Rao YN, Kumar MR, Venkata A, Rao NA, Prabhakar MC, Reddy BM
Antinociceptive and anti-inflammatory activity of carumbelloside I isolated from Caralluma umbellata
Journal of Ethnopharmacology 68(1-3) (1999)
349-352
The phytochemical study using Caralluma umbellata (Asclepiadaceae) whole plant allowed the isolation of a novel pregnane glycoside named carumbelloside I (3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-3β,14β-dihydroxypregn-5-en-20-one). Carumbelloside I was evaluated for both antinociceptive activity and anti-inflammatory activity. The antinociceptive activity was evaluated in mice using the writhing test method, while the anti-inflammatory activity was evaluated in rats using the paw edema test with carrageenin. Carumbelloside I has significant antinociceptive action. It has no anti-inflammatory activity.
Asclepiadaceae, pregnane glycoside, Caralluma umbellata, antinociceptive activityAnti-inflammatory activity, carumbelloside-I, 3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-3β, 14β-dihydroxypregn-5-en-20-one
NCBI PubMed ID: 10624901Publication DOI: 10.1016/S0378-8741(99)00122-1Journal NLM ID: 7903310Publisher: Limerick: Elsevier Sequoia
Institutions: University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, India, G. Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad 500 028, India
Methods: statistical analysis, anti-inflammation assay, antinociception assay, writhing test
The publication contains the following compound(s):
- Compound ID: 26317
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b-D-Glcp-(1-6)-b-D-Glcp-(1-3)-Subst
Subst = pregn-5-en-3β,14β-diol-20-one = SMILES CC([C@H]1CC{14}[C@]2(O)[C@]3([H])CC=C4C{3}[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O |
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Structure type: oligomer
Trivial name: carumbelloside I
Compound class: saponin glycoside, glycoside
Reference(s) to other database(s): CCSD:
39043, CBank-STR:4192
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