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1. (Article ID: 11794)
 
Park HJ, Lee MS, Lee KT, Sohn IC, Han YN, Miyamoto KI
Studies on constituents with cytotoxic activity from the stem bark of Syringa velutina
Chemical and Pharmaceutical Bulletin 47(7) (1999) 1029-1031
 

Cytotoxic compounds, oleuropein (1) and a phenylethanoid glycoside (2) were isolated from the stem bark of Syringa velutina KOM. along with coniferylaldehyde 4-O-glucoside, syringin, ligstroside, (+)-syringaresinol 4-O-glucoside, (+)-medioresinol 4"-O-glucoside and (-)-olivil 4"-O-glucoside. Phenylethanoid glycoside (2) was identified to be 3,4-dihydroxyphenylethyl alcohol 8-O-β-D-glucopyranoside. THis compound showed the most potent cytotoxic effect on several tumor cell lines (P-388, L-1210, SNU-5 and HL-60) among eitht compounds isolated in the present study. We suggest that the 3,4-dihydroxyphenylethoxy moiety of this compound contributes to cytotoxicity.

3, cytotoxicity, tumor cell, phenylethanoid glycoside, oleuropein, Syringa velutina, 4-dihydroxyphenylethy alcohol 8-O-β-D-glucopyranoside

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