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1. (Article ID: 11800)
Kong LD, Wolfender JL, Cheng CHK, Hostettmann K, Tan RX
Xanthine oxidase inhibitors from Brandisia hancei
Planta Medica 65(8) (1999)
744-746
Xanthine oxidase is a key enzyme associated with the incidence of hyperuricemia-related disorders. Repeated chromatography of the enzyme inhibitory part of the water extract of the twigs and leaves of Brandisia hancei (Scrophulariaceae) gave a flavone luteolin, an iridoid glycoside mussaenoside, two β-sitosterol glycosides daucosterol and β-sitosterol gentiobioside, and five phenylethanoids arenarioside, brandioside, acteoside, 2'-O-acetylacteoside and isoacteoside. Luteolin and isoacteoside inhibited the xanthine oxidase (XO, EC 1.2.3.2) with the IC50 values at 7.83 and 45.48 μM, respectively. Isoacteoside was found to be the first phenylethanoid that decreased substantially the formation of uric acid by inhibiting competitively xanthine oxidase (K(i) value: 10.08 μM). Furthermore, the study suggested that the caffeoylation of the 6'-hydroxyl group of the phenylethanoids was essential for the enzyme inhibitory action.
inhibitor, Brandisia hancei, xanthine oxidase
NCBI PubMed ID: 10630118Publication DOI: 10.1055/s-2006-960854Journal NLM ID: 0066751Publisher: George Thieme
Correspondence: Tan RX
netra.nju.edu.cn>
Institutions: Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, China, Institute of Pharmacognosy & Phytochemistry, School of Pharmacy, University of Lausanne, BEP, Lausanne-Dorigny, Switzerland
Methods: 13C NMR, 1H NMR, FAB-MS, inhibition studies, TLC, MS, HPLC, UV, optical rotation measurement, HMBC, HMQC, DEPT, COSY, LC-UV
The publication contains the following compound(s):
- Compound ID: 20490
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b-D-Glcp-(1-3)-Subst
Subst = β-sitosterol = SMILES O{3}[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@@]2([H])CC[C@@]4(C)[C@]3([H])CC[C@]4([C@@H](C)CC[C@@H](CC)C(C)C)[H] |
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Structure type: monomer
Trivial name: daucosterol, β-daucosterol, β-sitosterol, β-sitosterol-β-D-glucoside, androsine, saxifragifolin B, β-sitosterol 3-O-β-D-glucopyranoside
Compound class: saponin glycoside, glycoside, steroid glycoside, triterpenoid glycoside
Reference(s) to other database(s): GenDB:MK026953.1
- Compound ID: 22429
Structure type: oligomer
Trivial name: acteoside, verbascoside, acteoside, verbascoside, trans-verbascoside, verbascoside, acteoside
Compound class: saponin glycoside, glycoside, phenolic glycoside, phenylethanoid glycoside, phenylpropanoid glycoside, iridoid glycoside, lignan glycoside
- Compound ID: 22430
Structure type: oligomer
Trivial name: acteoside isomer, isoacteoside, isoverbascoside
Compound class: saponin glycoside, glycoside, phenolic glycoside, phenylethanoid glycoside
- Compound ID: 22431
Structure type: oligomer
Trivial name: 2'-acetylacteoside
Compound class: glycoside, phenylethanoid glycoside
- Compound ID: 27208
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b-D-Glcp-(1-1)-Subst11Me
Subst = mussaenosidic acid aglycon = SMILES C{10}[C@]1(O)CC[C@H]2[C@@H]1{1}[C@H](O)OC=C2{11}C(O)=O |
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Structure type: monomer
Trivial name: mussaenoside, penstemide
Compound class: glycoside, iridoid glycoside
Reference(s) to other database(s): CCSD:
49802, CBank-STR:1149
- Compound ID: 29460
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b-D-Xylp-(1-6)-+
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a-L-Rhap-(1-3)-b-D-Glcp-(1-8)-3,4,8HOPhet
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Caf-(9-4)-+ |
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Structure type: oligomer
Trivial name: arenarioside
Compound class: glycoside, phenolic glycoside, phenylethanoid glycoside, phenylpropanoid glycoside
- Compound ID: 30493
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a-L-Rhap-(1-6)-+
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a-L-Rhap-(1-3)-b-D-Glcp2Ac-(1-8)-3,4,8HOPhet
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Caf-(9-4)-+ |
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Structure type: oligomer
Trivial name: brandioside
Compound class: phenylethanoid glycoside
- Compound ID: 30494
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b-D-Glcp-(1-6)-b-D-Glcp-(1-3)-Subst
Subst = β-sitosterol = SMILES O{3}[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@@]2([H])CC[C@@]4(C)[C@]3([H])CC[C@]4([C@@H](C)CC[C@@H](CC)C(C)C)[H] |
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Structure type: oligomer
Trivial name: sterylglycoside SG-I
Compound class: saponin glycoside
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2. (Article ID: 12226)
He Z-D, Lau KM-, Xu H-X, Li P-C, Pui-Hay But P
Antioxidant activity of phenylethanoid glycosides from Brandisia hancei
Journal of Ethnopharmacology 71(3) (2000)
483-486
Brandisia hancei is a medicinal herb in China. The ethanol extract of this plant and four phenylethanoid glycosides, acteoside (1), 2'-acetylacteoside (2), poliumoside (3) and brandioside (4), isolated from it were shown to have inhibitory effects on free radical-induced hemolysis of red blood cells and free radical scavenging activities in vitro. Brandioside (4) and poliumoside (3) showed stronger antioxidant effect than acteoside (1), 2'-acetylacteoside (2) and trolox.
Antioxidant, phenylethanoid glycoside, Scrophulariaceae, Brandisia hancei
NCBI PubMed ID: 10940587Publication DOI: 10.1016/s0378-8741(00)00189-6Journal NLM ID: 7903310Publisher: Limerick: Elsevier Sequoia
Correspondence: paulbut
cuhk.edu.hk
Institutions: Institute of Chinese Medicine and Department of Biology, The Chinese Uni6ersity of Hong Kong, Shatin, Hong Kong, China
Methods: biological assays, colorimetry, extraction, chromatography, antioxidant activity test
The publication contains the following compound(s):
- Compound ID: 22429
Structure type: oligomer
Trivial name: acteoside, verbascoside, acteoside, verbascoside, trans-verbascoside, verbascoside, acteoside
Compound class: saponin glycoside, glycoside, phenolic glycoside, phenylethanoid glycoside, phenylpropanoid glycoside, iridoid glycoside, lignan glycoside
- Compound ID: 31768
Structure type: oligomer
Trivial name: 2'-O-acetylacteoside
Compound class: glycoside, phenolic glycoside
- Compound ID: 31769
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Caf-(9-4)-+
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a-L-Rhap-(1-2)-a-L-Rhap-(1-3)-b-D-Glcp-(1-8)-3,4,8HOPhet |
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Structure type: oligomer
Compound class: glycoside, phenolic glycoside
- Compound ID: 31770
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Caf-(9-4)-+
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a-L-Rhap-(1-4)-a-L-Rhap2Ac-(1-3)-b-D-Glcp-(1-8)-3,4,8HOPhet |
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Structure type: oligomer
Compound class: glycoside, phenolic glycoside
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