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1. (Article ID: 11802)
Akcoş Y, Ezer N, Calis I, Demirdamar R, Tel BC
Polyphenolic compounds of Sideritis lycia and their anti-inflammatory activity
Pharmaceutical Biology 37(2) (1999)
118-122
Four phenylpropanoid glycosides lavandulifolioside 1, martynoside 2, verbascoside (= acteoside) 3 and leucosceptoside A 4, were isolated from aerial parts of Sideritis lycia Boiss. et Heldr. (Lamiaceae). Their structures were determined by chromatographic and spectroscopic methods (UV, IR, 1H-NMR, 13C-NMR, FAB-MS). These compounds and flavonoid glycosides isolated from the same plant in our previously study were screened for their anti-inflammatory activity using the carrageenan-induced mouse paw edema test. The active compounds were investigated for their effect on gastric ulceration. Although flavonoid glycosides showed higher activity than the phenylpropanoid glycosides, the gastric ulceration effect of phenylpropanoid glycosides was less than flavonoid glycosides.
anti-inflammatory activity, flavonoid glycosides, phenylpropanoid glycosides, Lamiaceae, Sideritis lycia, gastric ulceration
Publication DOI: 10.1076/phbi.37.2.118.6081Journal NLM ID: 9812552Publisher: Lisse, the Netherlands: Swets & Zeitlinger
Institutions: Departament of Pharmacognosy, Faculty of Pharmacy, University of Hacettepe, Turkey, Departament of Pharmaceutical Botany, Faculty of Pharmacy, University of Hacettepe, Turkey, Departament of Pharmacology, Faculty of Pharmacy, University of Hacettepe, Turkey
Methods: 13C NMR, 1H NMR, IR, FAB-MS, TLC, UV, statistical analysis, MPLC, anti-inflammatory assays
The publication contains the following compound(s):
- Compound ID: 22429
Structure type: oligomer
Trivial name: acteoside, verbascoside, acteoside, verbascoside, trans-verbascoside, verbascoside, acteoside
Compound class: saponin glycoside, glycoside, phenolic glycoside, phenylethanoid glycoside, phenylpropanoid glycoside, iridoid glycoside, lignan glycoside
- Compound ID: 30240
Structure type: oligomer
Trivial name: martynoside
Compound class: glycoside, phenylethanoid glycoside, phenylpropanoid glycoside
- Compound ID: 30496
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Caf-(9-4)-+
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a-L-Arap-(1-2)-a-L-Rhap-(1-3)-b-D-Glcp-(1-8)-3,4,8HOPhet |
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Structure type: oligomer
; 779 [M+Na]+
Trivial name: lavandulifolioside
Compound class: phenylpropanoid glycoside
- Compound ID: 30497
Structure type: oligomer
Trivial name: leucosceptoside A
Compound class: glycoside, phenolic glycoside, phenylpropanoid glycoside
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