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1. (Article ID: 11882)
Mimaki Y, Kuroda M, Asano T, Sashida Y
Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells
Journal of Natural Products 62(9) (1999)
1279-1283
Two new triterpene saponins (8 and 9) and seven previously reported triterpene saponins (1-7) based upon oleanolic acid or hederagenin, along with two known lignans, (+)-pinoresinol (10) and β-peltatin (11), were isolated from a saponin fraction prepared from the MeOH extract of the roots of Pulsatilla chinensis. The structures of the new saponins were determined by spectroscopic analysis, including 2D NMR spectroscopic techniques, and the results of hydrolytic cleavage. The isolated compounds and some derivatives were evaluated for their cytotoxic activity against HL-60 human leukemia cells.
cytotoxic activity, triterpene saponin, Pulsatilla chinensis
NCBI PubMed ID: 10514313Publication DOI: 10.1021/np9901837Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: Mimaki Y
ps.toyaku.ac.jp>
Institutions: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan
Methods: 13C NMR, 1H NMR, methylation, IR, FAB-MS, TLC, HPLC, optical rotation measurement, TOCSY, cytotoxicity assay, HMQC, DEPT, COSY, MTT, HR-FAB-MS, HCl hydrolysis
The publication contains the following compound(s):
- Compound ID: 23964
Structure type: oligomer
C41H66O12
Trivial name: Kalopanax-saponin A, α-hederin, kalopanaxsaponin A
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
Reference(s) to other database(s): CCSD:
39886, CBank-STR:2464
- Compound ID: 24173
Structure type: oligomer
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
Reference(s) to other database(s): CCSD:
32232, CBank-STR:6400
- Compound ID: 30392
Structure type: oligomer
Trivial name: β-hederin
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
- Compound ID: 30749
Structure type: oligomer
Compound class: saponin glycoside
- Compound ID: 30750
Structure type: oligomer
Compound class: saponin glycoside
- Compound ID: 30751
Structure type: oligomer
; 949 [M+Na]+
Compound class: saponin glycoside
- Compound ID: 30752
Structure type: oligomer
Trivial name: hederacolchiside A'
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
- Compound ID: 30753
Structure type: oligomer
Trivial name: hederacolchiside A
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
- Compound ID: 30754
|
b-D-Glcp-(1-4)-b-D-Glcp-(1-3)-a-L-Rhap-(1-2)-a-L-Arap-(1-3)-Oleanolic |
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Structure type: oligomer
; 1081.5565 [M+Na]+
C53H86O21
Compound class: saponin glycoside
- Compound ID: 30755
|
b-D-Glcp-(1-4)-b-D-Glcp-(1-3)-a-L-Rhap-(1-2)-a-L-Arap-(1-3)-Oleanolic28Me |
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Structure type: oligomer
; 1095 [M+Na]+
Compound class: saponin glycoside
- Compound ID: 30756
|
b-D-Glcp-(1-4)-+
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b-D-Glcp-(1-4)-b-D-Glcp-(1-3)-a-L-Rhap-(1-2)-a-L-Arap-(1-3)-Oleanolic |
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Structure type: oligomer
; 1243.6179 [M+Na]+
C59H96O26
Compound class: saponin glycoside
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