Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
NCBI PubMed ID: 6518590Publication DOI: 10.1248/cpb.32.3128Journal NLM ID: 0377775Publisher: Pharmaceutical Society Of Japan
Institutions: School of Pharmaceutical Sciences, Showa University, Tokyo, Japan, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Tokyo, Japan, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima Japan, Meiji College of Pharmacy, Tokyo, Japan
Potentiation of the nerve growth factor (NGF)-mediated nerve fiber production in organ cultures of chicken embryonic dorsal root ganglia (DRG) and lumbar sympathetic ganglia (SymG) by saponins isolated from Panax ginseng C. A. MAYER and Panax japonicum C. A. MAYER and related compounds was studied in order to elucidate the structure-activity relationship. Panax saponins and related compounds so far tested did not promote nerve fiber production, but some 20 (S)-protopanaxadiol glycoside having glucose units in their two sugar moieties potentiated the effect of NGF. Removal of glucose or introduction of a hydroxy group into the side chain of ginsenoside Rd reduced the activity. Little difference was observed in the potentiation of the NGF effect by the saponins in organ cultures of DRG and SymG.
tissue culture, Panax ginseng, saponin, nerve growth factor
Structure type: oligomer
Location inside paper: table I
Trivial name: ginsenoside-F2, ginsenoside F2
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: nerve fiber production test
Biological activity: promotes nerve fiber production
NCBI Taxonomy refs (TaxIDs): 4054,
44685Reference(s) to other database(s): CCSD:
27076, CBank-STR:2956
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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