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1. (Article ID: 12052)
 
Capasso A, Saturnino P, Simone FD, Aquino R
Flavonol glycosides from Aristeguietia discolor reduce morphine withdrawal in vitro
Phytotherapy Research 14(7) (2000) 538-540
 

The effects of extracts, partially purified fractions and four flavonol glycosides 1-4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong contraction of guinea-pig isolated ileum was observed after the addition of naloxone. Both MeOH extract (50, 100 and 200 mg/mL), the partially purified fractions I, L, M and N (50, 100 and 200 mg/mL) and flavonol glycosides 1-4 (100, 50, 10 μM), injected 10 min before morphine, were capable of blocking the naloxone-induced contraction after exposure to morphine in a concentration-dependent fashion. The results of the present paper suggest that flavonol glycosides from Aristeguietia discolor may play an important role in the control of morphine withdrawal.

guinea-pig ileum, Aristeguietia discolor, morphine, naloxone

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