Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: fruit
The structure was elucidated in this paperNCBI PubMed ID: 7541317Publication DOI: 10.1248/cpb.43.641Journal NLM ID: 0377775Publisher: Pharmaceutical Society Of Japan
Institutions: Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Japan, Faculty of Pharmacy, Cairo University, Egypt
Extracts of 41 medicinal plants used in Egyptian folk medicine were screened for their inhibitory effects on human immunodeficiency virus-1 reverse transcriptase. The extracts of fruits of Phyllanthus emblica, Quercus pedunculata, Rumex cyprius, Terminalia bellerica, Terminalia chebula and Terminalia horrida showed significant inhibitory activity with IC_<50>≦50 μg/ml. Through a bioassay guided-fractionation of the methanol extract of the fruit of P. emblica, putranjivain A (1) was isolated as a potent inhibitory substance with IC_<50>=3.9 μM, together with 1,6-di-O-galloyl-β-D-glucose (2), 1-O-galloyl-β-D-glucose (3), kaempferol-3-O-β-D-glucoside (4), quercetin-3-O-β-D-glucoside (5) and digallic acid (6). The inhibitory mode of action by 1,2 and 6 was non-competitive with respect to the substrate but competitive with respect to a template-primer. Furthermore, the stereochemistry of 1 was established in this paper by nuclear magnetic resonance spectroscopy.
Hiv-1, reverse transcriptase inhibition, Egyptian folk medicine, Phyllanthus emblica, tannins, putranjivain A
Structure type: monomer ; 463 [M-H]-
C
21H
20O
12Location inside paper: 5
Trivial name: isoquercitrin
Compound class: glycoside, flavonol glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, FAB-MS, TLC, UV, biological assay
Related record ID(s): 62231
NCBI Taxonomy refs (TaxIDs): 296036Reference(s) to other database(s): CCSD:
4754, CBank-STR:953
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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