Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
NCBI PubMed ID: 9396160Publication DOI: 10.1248/cpb.45.1823Journal NLM ID: 0377775Publisher: Pharmaceutical Society Of Japan
Institutions: Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan
The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 25-50 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.
Structure type: monomer
Location inside paper: Tetrahydroswertianolin
Trivial name: swertianolin
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, IR, FAB-MS, UV, optical rotation measurement, HR-FAB-MS, 1H-13C COSY, 1H-13C long range COSY, 1H1H COSY
Biological activity: Hepatoprotective effect D-galactosamine/lipopolysaccharide-induced, liver injury in mice
NCBI Taxonomy refs (TaxIDs): 137129Reference(s) to other database(s): CCSD:
12148, CBank-STR:22222
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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