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1. (Article ID: 12084)
Cho JY, Baik KU, Yoo ES, Yoshikawa K, Park MH
In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica
Journal of Natural Products 63(9) (2000)
1205-1209
Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-α and nitric oxide (NO) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various mitogens, in a dose-dependent manner. The results indicate that the woorenosides strongly inhibit the mitogenic response by activated macrophage and lymphocytes and suggest that these compounds may participate in regulating inflammatory processes.
antitumor activity, Coptis japonica, neolignans, woorenosides
NCBI PubMed ID: 11000020Publication DOI: 10.1021/np9902791Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: Cho JY
ucl.ac.uk>
Institutions: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Japan, Department of Immunopharmacology, R&D Center, Daewoong Pharmaceutical Co. Ltd., Sungnam, South Korea, Department of Immunology, Windeyer Institute of Medical Sciences, University College London Medical School, London, UK
Methods: ELISA, biological assays, extraction, cell growth, determination of NO production, cytotoxicity assay, antitumor activity assay, MTT, optical density measurement, splenocyte proliferation assay, proliferation assay
The publication contains the following compound(s):
- Compound ID: 31454
|
b-D-Glcp-(1-10)-Subst
Subst = woorenoside I-IV aglycon = SMILES COC1=CC(/C=C/{10}CO)=CC2=C1O[C@@H](C3=CC(OC)=C(OC)C(OC)=C3)[C@@H]2{11}CO |
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Structure type: monomer
Trivial name: woorenoside I
Compound class: glycoside
- Compound ID: 31455
|
b-D-Glcp-(1-10)-Subst11Ac
Subst = woorenoside I-IV aglycon = SMILES COC1=CC(/C=C/{10}CO)=CC2=C1O[C@@H](C3=CC(OC)=C(OC)C(OC)=C3)[C@@H]2{11}CO |
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Structure type: monomer
Trivial name: woorenoside II
Compound class: glycoside
- Compound ID: 31456
|
Subst1-(1-6)-b-D-Glcp-(1-10)-Subst
Subst = woorenoside I-IV aglycon = SMILES COC1=CC(/C=C/{10}CO)=CC2=C1O[C@@H](C3=CC(OC)=C(OC)C(OC)=C3)[C@@H]2{11}CO;
Subst1 = 4-hydroxy-2-Methylenebutanoic acid = SMILES C=C(C{4}CO){1}C(=O)O |
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Structure type: monomer
Trivial name: woorenoside III
Compound class: glycoside
- Compound ID: 31457
|
Subst1-(1-6)-b-D-Glcp-(1-10)-Subst11Ac
Subst = woorenoside I-IV aglycon = SMILES COC1=CC(/C=C/{10}CO)=CC2=C1O[C@@H](C3=CC(OC)=C(OC)C(OC)=C3)[C@@H]2{11}CO;
Subst1 = 4-hydroxy-2-Methylenebutanoic acid = SMILES C=C(C{4}CO){1}C(=O)O |
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Structure type: monomer
Trivial name: woorenoside IV
Compound class: glycoside
- Compound ID: 31458
|
Subst1-(1-6)-b-D-Glcp-(1-11)-Subst
Subst = (-)-dehydrodiconiferyl alcohol = SMILES COc3cc([C@@H]2Oc1c(OC)cc(/C=C/{11}CO)cc1[C@H]2{12}CO)cc{54}c3O;
Subst1 = 4-hydroxy-2-Methylenebutanoic acid = SMILES C=C(C{4}CO){1}C(=O)O |
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Structure type: monomer
Trivial name: woorenoside V
Compound class: glycoside
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