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1. (Article ID: 12118)
Deepak M, Handa SS
Antiinflammatory activity and chemical composition of extracts of Verbena officinalis
Phytotherapy Research 14(6) (2000)
463-465
n an attempt to locate the biologically active fraction(s) of the plant Verbena officinalis Linn. (Verbenaceae), a preliminary screening of successive petroleum ether, chloroform and methanol extracts of aerial parts for antiinflammatory activity using carrageenan paw oedema model was carried out. All three extracts were found to exhibit antiinflammatory activity with the chloroform extract being the most active. Chemical investigations of petroleum ether and chloroform extracts led to the isolation of β-sitosterol, ursolic acid, oleanolic acid, 3-epiursolic acid, 3-epioleanolic acid, and minor triterpenoids of derivatives of ursolic acid and oleanolic acids. Chromatographic purification of the methanol extract yielded two iridoid glucosides, verbenalin and hastatoside, a phenylpropanoid glycoside, verbascoside and β-sitosterol-D-glucoside.
β-sitosterol, ursolic acid, oleanolic acid, Verbenaceae, verbascoside, Verbena officinalis, verbenalin, hastatoside, antiinflammatory, oedema inhibition, 3-epiursolic acid, 3-epioleanolic acid, β-sitosterol-D-glucoside
NCBI PubMed ID: 10960904Publication DOI: 10.1002/1099-1573(200009)14:6<463::aid-ptr611>3.0.co;2-gJournal NLM ID: 8904486Publisher: Chichester: Wiley
Correspondence: Handa SS
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Institutions: Regional Research Laboratory (C.S.I.R.), Jammu, India
Methods: 13C NMR, 1H NMR, biological assays, MS, HPLC, extraction, HPTLC, CC, evaporation, anti-inflammatory assays
The publication contains the following compound(s):
- Compound ID: 20490
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b-D-Glcp-(1-3)-Subst
Subst = β-sitosterol = SMILES O{3}[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@@]2([H])CC[C@@]4(C)[C@]3([H])CC[C@]4([C@@H](C)CC[C@@H](CC)C(C)C)[H] |
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Structure type: monomer
Trivial name: daucosterol, β-daucosterol, β-sitosterol, β-sitosterol-β-D-glucoside, androsine, saxifragifolin B, β-sitosterol 3-O-β-D-glucopyranoside
Compound class: saponin glycoside, glycoside, steroid glycoside, triterpenoid glycoside
Reference(s) to other database(s): GenDB:MK026953.1
- Compound ID: 22429
Structure type: oligomer
Trivial name: acteoside, verbascoside, acteoside, verbascoside, trans-verbascoside, verbascoside, acteoside
Compound class: saponin glycoside, glycoside, phenolic glycoside, phenylethanoid glycoside, phenylpropanoid glycoside, iridoid glycoside, lignan glycoside
- Compound ID: 31372
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b-D-Glcp-(1-1)-Subst
Subst = hastatoside aglycon = SMILES COC(=O)/C1=C/O{1}[C@@H](O)C2[C@@H](C)CC(=O){5}[C@]12O |
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Structure type: monomer
Trivial name: hastatoside
Compound class: glycoside
- Compound ID: 31513
Structure type: monomer
Trivial name: verbenalin
Compound class: glycoside
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