Antitumor effect of the stem bark of Acanthopanax senticosus HARMS (ASH) from Hokkaido (Japanese name: Ezoukogi) on human stomach cancer KATO III cells was investigated. The extract of the stem bark of ASH prepared with hot water was dissolved in distilled water and used for the assay of antitumor effect on the KATO III cells. The exposure of KATO III cells to ASH led to both growth inhibition and induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with ASH. The fragmentation by ASH of DNA to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. We have investigated which component in ASH is effective on the induction of apoptosis. Among chlorogenic acid, syringaresinol di-O-β-D glucoside, syringin, and sesamin, components of the n-butanol extract prepared from ASH, sesamin suppressed the growth and induced apoptosis in the cells. These findings suggest that growth inhibition by ASH results from the apoptosis induced by sesamin, a component of ASH.

apoptosis, ASH, Acanthopanax senticosus HARMS, sesamin, growth inhibition, DNA fragmentation, stomach cancer, KATO III cells

• Compound ID: 29387
  

  b-D-Glcp-(1-4')-+ | b-D-Glcp-(1-4")-Subst Subst = syringaresinol = SMILES COC1=CC(C2C3COC(C4=CC(OC)={104}C(O)C(OC)=C4)C3CO2)=CC(OC)={54}C1O

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  Structure type: oligomer
  Trivial name: liriodendrin
  Compound class: glycoside
  
   
  
  Acanthopanax senticosus
  CSDB ID 65775 (all data & tools)