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1. (Article ID: 12255)
 
Imai H, Morimoto Y, Tamura K
Sphingoid base composition of monoglucosylceramide in Brassicaceae
Journal of Plant Physiology 157(4) (2000) 453-456
 

The sphingoid base composition of monoglucosylceramide was examined in leaves and roots of six species of the family Brassicaceae. The major components of the nine sphingoid bases we detected were 4-hydroxy-8-sphingenine [i.e. t18:1 (8E) and (8Z)] and 8-sphingenine, in both leaves and roots. The composition was unique because the relative proportions of 8-E/Z isomers in 4-hydroxy-8-sphingenine and in 8-sphingenine were different. So far, only chilling-resistant plants have been found to contain more t18:1 (8Z) components than t18:1 (8E) [Imai et al. (1997) Biosci Biotechnol Biochem 61:351-353]. Species of the family Brassicaceae can now be added to this list.

Arabidopsis thaliana, sphingolipid, cerebroside, Brassicaceae, long chain base

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2. (Article ID: 12521)
 
Nastruzzi C, Cortesi R, Esposito E, Menegatti E, Leoni O, Iori R, Palmieri S
In vitro antiproliferative activity of isothiocyanates and nitriles generated by myrosinase-mediated hydrolysis of glucosinolates from seeds of cruciferous vegetables
Journal of Agricultural and Food Chemistry 48(8) (2000) 3572-3575
 

A comparison of the effect of isothiocyanates and nitriles derived from some glucosinolates, namely, epi-progoitrin, sinalbin, glucotropaeolin, glucocheirolin, and glucoraphenin, on human erythroleukemic in vitro cultured cells was studied. Many studies have in fact evidenced that a consumption of vegetable containing glucosinolates could reduce the development of colorectal cancer. In the experimental conditions used, the production of isothiocyanates and nitriles from glucosinolates is almost quantitative as confirmed by HPLC or GC-MS analysis. The obtained results demonstrated that in general nitriles are considerably less potent than the corresponding isothiocyanates in inhibiting cancer cell growth. Particularly, the isothiocyanates inhibitory activity on K562 cells growth is higher in the case of products derived from epi-progoitrin, glucotropaeolin, glucoraphenin, and glucocheirolin; while for nitriles the higher activity in inhibiting K562 cells growth is showed by sinalbin-derived product. Considering the antiproliferative activity found for isothiocyanates and nitriles, further studies will be aimed to the possible application of glucosinolate-derived products as chemopreventive cancer agents for the reduction of colorectal cancer.

enzymes and enzyme reactions; antitumor compounds; antiproliferative agents

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