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1. (Article ID: 12342)
Lee MW, Kim JH, Jeong DW, Ahn KH, Toh SH, Surh YJ
Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica
Biological and Pharmaceutical Bulletin 23(4) (2000)
517-518
Two known diarylheptanoids, oregonin (1), (5S)-1, 7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-xylopyranoside and hirsutanonol (2), (5S)-1, 7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCDF10A cells.
Alnus hirsuta var. sibirica, cyclooxygenase-2 inhibitor, diarylheptanoid
NCBI PubMed ID: 10784440Publication DOI: 10.1248/bpb.23.517Journal NLM ID: 9311984Publisher: Pharmaceutical Society of Japan
Institutions: College of Pharmacy, Chung-Ang University, Seoul, South Korea, College of Pharmacy, Seoul National University, Seoul, South Korea, College of Pharmacy, Dong-Duk Woman's University, Seoul, South Korea
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