Found 2 publications. Displayed publications from 1 to 2
Expand all publications       Show all as text (SweetDB notation)
1. (Article ID: 12605)
 
Preobrazhenskaya MN, Korolev AM
Indole derivatives in vegetables of the Cruciferae family
Russian Journal of Bioorganic Chemistry 26(2) (2000) 85-97
 

The chemical background of the biological activities of vegetables of the Cruciferae family is considered. These vegetables contain alkaloids of the glucobrassicin group that are decomposed by the enzyme myrosinase (thioglucosidase, EC 3.2.3.1) released upon damage to the plant cells. This results in several indole derivatives, with ascorbigen and indole-3-carbinol predominating. In the gastrointestinal tract, these compounds form 5H,11H-indolo[3,2-b]carbazole, a natural ligand of the aromatic hydrocarbon receptor (Ah receptor) and a functional analogue of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a dangerous xenobiotic. The indolocarbazole—Ah receptor complex activates the gene of CYP1A1, an isoenzyme of cytochrome P450-dependent monoamine oxidase, which enhances the 2-hydroxylation (inactivation) of estrogens. In its turn, the resulting lowered level of estrogens inhibits the growth of hormone-dependent tumors or prevents their appearance. The mechanism of xenobiotic inactivation, underlying the anticarcinogenic action of food products including vegetables of the Cruciferae family and some homogeneous indole compounds, is similar. Some other effects of nutrient indole compounds, e.g., the inhibition of expression of the cyclin-dependent kinase 6 (CDK6) by indole-3-carbinol that leads to the cell cycle arrest in G1 phase, are also considered. Analysis of the biological effects of the Cruciferae diet has helped start clinical studies of indole-3-carbinol as an antitumor and anticarcinogenic remedy for patients with a high risk of tumor diseases.

aromatic hydrocarbon receptor, ascorbigen, cytochrome P450 monoamine oxidase, glucobrassicin alkaloids, indole-3-carbinol, indolocarbazole

The publication contains the following compound(s):
 

Expand this publication
2. (Article ID: 12906)
 
Ahmed KM, Marzouk MS, el-Khrisy EA, Wahab SA, el-Din SS
A new flavone diglycoside from Carthamus tinctorius seeds
Die Pharmazie 55(8) (2000) 621-622
 

From the aqueous ethanol extract (AE) of Carthamus tinctorius seeds, a new acacetin diglycoside has been isolated and identified as acacetin 7-O-β-D-apiofuranosyl-(1"'-->6" instead of 6')-O-β-D-glucopyranoside together with previously isolated kaempferol 7-O-β-D-glucopyranoside, acacetin 7-O-α-L-rhamnopyranoside and acacetin. The structures of these metabolites have been established on the basis of chemical, chromatographic and spectral methods.

The publication contains the following compound(s):
 

Expand this publication

Resort publications by:

New query Export IDs Home Help

Execution: <1 sec