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1. (Article ID: 12645)
 
Sallusto F, Poupot R, Clergue M, DePalma R, Fournié J-J
A flavonoid sulfate antigen activates human αβ CD8+ Th2 lymphocytes in pollen allergy
European Journal of Immunology 30(3) (2000) 964-968
 

Cellular immune responses are initiated when T lymphocytes expressing αβ TCR recognize peptide antigens bound to MHC molecules or, less frequently, double-stranded glycolipid antigens bound to CD1 molecules. In the allergy to Parietaria judaica, human αβ CD8+ Th2 lymphocytes react to a non-peptide pollinic antigen presented by B cells. The environmental allergen was purified and identified as a new flavonoid pigment: 2'-O-sulfate, 6-O-β-D-glucuronopyranosyl, 2',5,6-trihydroxy-isoflavone. Its specific recognition by αβ CD8+ Th2 T cells (1) depends upon an MHC- and CD1-independent presentation mediated by B cells, (2) is determined by the flavonoid carbohydrate and sulfate groups and (3) leads to positive skin prick test in allergic patients. Hence, an unusual mode of aromatic sulfated antigen recognition by αβ CD8+ Th2 T lymphocytes might underlie the cellular mediation of human allergy to plant allergens.

antigen, allergy, T lymphocyte, sulfated flavonoid

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