Leaf extracts of the Malaysian plant Aglaia laxiflora provided two cytotoxic compounds, a new rocaglaol rhamnoside (1), a known rocaglaol (2), new (but inactive) flavonol-cinnamaminopyrrolidine adducts (3-6), and their probable biosynthetic precursors (7 and trimethoxyflavonol). All structures were elucidated primarily by 2D NMR spectroscopy. The structure and stereochemistry of aglaxiflorin A (3) were confirmed by single-crystal X-ray crystallography.

structure, Aglaia laxiflora, rocaglaol rhamnoside

NCBI PubMed ID: 10785416
Publication DOI: 10.1021/np990454d
Journal NLM ID: 7906882
Publisher: American Society of Pharmacognosy
Correspondence: chmgshleonis.nus.edu.sg
Institutions: Department of Chemistry, National University of Singapore, Singapore, Department of Pharmacology, National University of Singapore, Singapore, Forest Research Center, Sepilok, Malaysia, Forest Research Institute of Malaysia, Kepong, Malaysia
Methods: 13C NMR, 1H NMR, NMR-2D, FAB-MS, TLC, ESI-MS, HPLC, extraction, CC
 

• Compound ID: 33360
  

  a-L-Rhap-(1-1)-Subst Subst = rocaglaol = SMILES COC1=CC=C([C@]23[C@H](C4=CC=CC=C4)C{1}[C@@H](O){208}[C@@]2(O)C5=C(C=C(OC)C=C5OC)O3)C=C1

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  Structure type: monomer
  Compound class: glycoside
  
   
  
  Aglaia laxiflora
  CSDB ID 68672 (all data & tools)