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1. (Article ID: 12852)
Yao M, Qi Y, Bi K, Wang X, Luo X, Che C
A precolumn derivatization high-performance liquid chromatographic method with improved sensitivity and specificity for the determination of astragaloside IV in Radix astragali
Journal of Chromatographic Science 38(8) (2000)
325-328
A reversed-phase high-performance liquid chromatographic method is developed for the determination of astragaloside (AGS) IV, which is known as the active constituent of Radix Astragali. The method uses precolumn derivatization with benzoyl chloride to form the benzoyl ester of AGS IV quantitatively and is carried out with a wide-ranging concentration (0.004-0.080 mg/mL) of the derivatized AGS IV. The eluent consists of 90% methanol, 4% tetrahydrofuran, 6% water, and 0.2% triethylamine, with vitamin D3 added as the internal standard.
derivatives, RP-HPLC, Radix astragali, astragaloside IV, benzoylation
NCBI PubMed ID: 10955506Publication DOI: 10.1093/chromsci/38.8.325Journal NLM ID: 0173225Publisher: Oxford: Oxford University Press
Institutions: Shenyang Pharmaceutical University, Shenyang, China, Department of Chemistry, Hong Kong University of Science & Technology, School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Methods: HPLC, derivatization
The publication contains the following compound(s):
- Compound ID: 28879
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b-D-Glcp-(1-6)-+
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b-D-Xylp-(1-3)-Subst
Subst = astramembrangenin = SMILES CC1(C){3}[C@@H](O)CC[C@]2(C3)C43CC[C@]5(C)[C@@H]([C@](C)(O6)CC[C@H]6{25}C(C)(O)C){16}[C@@H](O)C[C@](C)5[C@]4([H])C{6}[C@H](O)[C@@]12[H] |
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Structure type: oligomer
Trivial name: astragaloside IV, astragalus saponin AS I, cycloastragenol
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
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