Amycolamicin is a new antibiotic, which has been isolated from the culture broth of Amycolatopsis sp. MK575-fF5 during our screening program for drug-resistant pathogens. Structurally, amycolamicin has unique features compared with other antibiotics; it contains trans-decalin, tetramic acid, two unusual sugars and pyrrole carbonic acid. Amycolamicin has bactericidal activity not only against a wide variety of bacteria but also against drug-resistant pathogens, methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, which are major pathogenic bacterial causes of hospital infections. There is a strong need to develop novel antibiotics with unique structures and modes of action because pathogens resistant to the ‘last resort’ antibiotic vancomycin have emerged. Judging from the present situation, amycolamicin could be considered as a potential candidate antibiotic
antibiotic, amycolamicin, amycolose, Amycolatopsis sp. MK575-fF5
NCBI PubMed ID: 20111064Publication DOI: 10.1038/ja.2010.1Journal NLM ID: 0151115Publisher: London: Nature Publishing Group
Correspondence: tohyamas@bikaken.or.jp
Institutions: Microbial Chemistry Research Center, Microbial Chemistry Research Foundation, Tokyo, Japan
Methods: 13C NMR, 1H NMR, IR, methanolysis, optical rotation measurement, isotopic labeling, cell growth, HR-ESI-MS, centrifugal partition chromatography
Found