During the course of screening program for new antitumor antibiotics, three active substances has been isolated which were named kerriamycins A, B and C, respectively, from the culture broth of a streptomycete. These antibiotics inhibit the growth of Gram-positive bacteria and prolong the survival periods of mice bearing Ehrlich ascites carcinoma.
antibiotics, kerriamycins, Streptomyces violaceolatus
NCBI PubMed ID: 3839784Publication DOI: 10.7164/antibiotics.38.960Journal NLM ID: 0151115Publisher: London: Nature Publishing Group
Institutions: Institute of Applied Microbiology, The University of Tokyo, Tokyo, Japan, Applied Bioscience Laboratory Kirin Brewery Co. Ltd., Maebashi, Japan
Methods: 13C NMR, IR, FAB-MS, acid hydrolysis, composition analysis, UV, extraction, optical rotation measurement, CC, cell growth, melting point determination, antibacterial assay, antitumor activity assay, evaporation, antifungal activity test
Found