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Structure type: oligomer ; 845 [M+Na]+
C₄₃H₅₀O₁₆
Trivial name: PI-083
Compound class: C-glycoside

• Article ID: 5375
  Kawashima A, Yoshimura Y, Goto J, Nakaike S, Mizutani T, Hanada K, Omura S "PI-083, a new platelet aggregation inhibitor" - The Journal of Antibiotics 41(12) (1988) 1913-1914
  

  In the course of screening program for platelet aggregation inhibitor from a microbial origin, new compound PI-083 has been isolated from the fermentation broth of Streptomyces matensis A-6621.

  Streptomyces matensis, platelet aggregation inhibitor

  NCBI PubMed ID: 3209483
  Publication DOI: 10.7164/antibiotics.41.1913
  Journal NLM ID: 0151115
  Publisher: London: Nature Publishing Group
  Institutions: Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan
  Methods: 13C NMR, 1H NMR, IR, inhibition studies, HPLC, UV, optical rotation measurement, elemental analysis, CC, cell growth, melting point determination, antibacterial assay, centrifugation, COSY, SI-MS, HOHAHA
  
   
  
  Streptomyces matensis A-6621
  CSDB ID 46018 (all data & tools)

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Structure type: oligomer
Trivial name: urdamycin A
Compound class: C-glycoside, angucycline polyketide glycoside

• Article ID: 6197
  Anh CV, Kwon JH, Kang JS, Lee HS, Heo CS, Shin HJ "New Angucycline Glycosides from a Marine-Derived Bacterium Streptomyces ardesiacus" - International Journal of Molecular Sciences 23(22) (2022) 13779
  

  Chemical investigation of the ethyl acetate extract from the culture broth of the marine-derived actinobacterium Streptomyces ardesiacus 156VN-095 led to the isolation of three hitherto undescribed angucycline glycosides, including urdamycins W and X (1 and 2) and grincamycin U (9), as well as their seven known congeners. The structures of the new compounds were elucidated by means of spectroscopic methods (HRESIMS, 1D and 2 D NMR) and comparison of their experimental data with literature values. Compounds 1-3 and 9 were evaluated for their anti-Gram-positive bacterial effect and cytotoxicity against six cancer cell lines. Compound 1 displayed significant cytotoxicity against all the tested cell lines with GI50 values of 0.019-0.104 µM. Collectively, these findings highlight the potential of angucycline glycosides as leading structures for the development of new anti-cancer drugs.

  cytotoxicity, anti-bacterial, grincamycin, Streptomyces ardesiacus, urdamycin

  NCBI PubMed ID: 36430256
  Publication DOI: 10.3390/ijms232213779
  Journal NLM ID: 101092791
  Publisher: Basel, Switzerland: MDPI
  Correspondence: H.J. Shin
  Institutions: Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea, Department of Marine Biotechnology, University of Science and Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon 34113, Korea, Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, HPLC, UV, fermentation, HR-ESI-MS, antibacterial assay, cytotoxicity assay, isolation
  
   
  
  Streptomyces ardesiacus 156VN-095
  CSDB ID 8591 (all data & tools)