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Structure type: oligomer ; 786.2887
C₄₃H₄₆O₁₄
Trivial name: moromycin A
Compound class: glycoside

• Article ID: 5542
  Abdelfattah MS, Kharel MK, Hitron JA, Baig I, Rohr J "Moromycins A and B: Isolation and structure elucidation of C-glycosylangucycline type antibiotics from Streptomyces sp.KY002" - Journal of Natural Products 71(9) (2008) 1569-1573
  

  Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

  Streptomyces, glycosides, antibiotics, moromycins, saquayamycin B, fridamycin D

  NCBI PubMed ID: 18666798
  Publication DOI: 10.1021/np800281f
  Journal NLM ID: 7906882
  Publisher: American Society of Pharmacognosy
  Correspondence: jrohr2@email.uky.edu
  Institutions: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, USA
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, DNA techniques, ESI-MS, HPLC, UV, extraction, optical rotation measurement, CI-MS, cell growth, HPLC-MS, cytotoxicity assay, antitumor activity assay, evaporation, centrifugation
  
   
  
  Streptomyces sp. KY002
  CSDB ID 47251 (all data & tools)

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Structure type: oligomer ; 562.1844
C₃₁H₃₀O₁₀
Trivial name: moromycin B
Compound class: glycoside

• Article ID: 5542
  Abdelfattah MS, Kharel MK, Hitron JA, Baig I, Rohr J "Moromycins A and B: Isolation and structure elucidation of C-glycosylangucycline type antibiotics from Streptomyces sp.KY002" - Journal of Natural Products 71(9) (2008) 1569-1573
  

  Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

  Streptomyces, glycosides, antibiotics, moromycins, saquayamycin B, fridamycin D

  NCBI PubMed ID: 18666798
  Publication DOI: 10.1021/np800281f
  Journal NLM ID: 7906882
  Publisher: American Society of Pharmacognosy
  Correspondence: jrohr2@email.uky.edu
  Institutions: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, USA
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, DNA techniques, ESI-MS, HPLC, UV, extraction, optical rotation measurement, CI-MS, cell growth, HPLC-MS, cytotoxicity assay, antitumor activity assay, evaporation, centrifugation
  
   
  
  Streptomyces sp. KY002
  CSDB ID 47252 (all data & tools)