Two new nikkomycins were isolated from the fermentation broth of Streptomyces tendae Tü 901/PF 53+ -3. These new metabolites, nikkomycins pseudo-Z (ψ-Z,1) and pseudo-J (ψ-J, 2) differ from the corresponding nikkomycins Z and J by a C-glycosidic bond between C-5 of uracil and C-1' of 5-amino-5-deoxy-D-allo-furanuronic acid instead of an N-glycosidic bond. The structure elucidation was achieved by two-dimensional NMR techniques and mass spectrometry
antibiotics, nikkomycins, Streptomyces tendae
NCBI PubMed ID: 2722685Publication DOI: 10.7164/antibiotics.42.711Journal NLM ID: 0151115Publisher: London: Nature Publishing Group
Institutions: Institute of Biology II, University Tübingen, Tübingen, Germany, Institute of Organic Chemistry, University Hamburg, Hamburg, Germany
Methods: 13C NMR, 1H NMR, FAB-MS, GC-MS, acid hydrolysis, derivatization, COSY