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1. (Article ID: 1422)
 
Edwards KJ, Jay AJ, Colquhoun IJ, Morris VJ, Gasson MJ, Griffin AM
Generation of a novel polysaccharide by inactivation of the aceP gene from the acetan biosynthetic pathway in Acetobacter xylinum
Microbiology 145(6) (1999) 1499-1506
 

The acetan biosynthetic pathway in Acetobacter xylinum is an ideal model system for engineering novel bacterial polysaccharides. To genetically manipulate this pathway, an Acetobacter strain (CKE5), more susceptible to gene-transfer methodologies, was developed. A new gene, aceP, involved in acetan biosynthesis was identified, sequenced and shown to have homology at the amino acid level with β-D-glucosyl transferases from a number of different organisms. Disruption of aceP in strain CKE5 confirmed the function assigned above and was used to engineer a novel polysaccharide with a pentasaccharide repeat unit.

acetan, Acetobacter xylinum, AceP gene, EPS biosynthesis and novel EPS

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