Kijanimicin, the major component of a complex of antibiotics produced by Actinomadura kijaniata nov. sp., has been shown to have the novel tetronic acid structure. Kijanimicin has antitumor activity and is active against P.acnes and is a member of a new class of tetronic acid containing antibiotics of which the tetrocarcins and antlermicins are the only other known members. The latter differ in the structure of the aglycon as well as in the structures of some of the glycosidic components, and full structures for these antiobiotics have not yet been published.
antibiotic, kijanimicin, Actinomadura kijaniata
Publication DOI: 10.1021/ja00403a063Journal NLM ID: 7503056Publisher: American Chemical Society
Institutions: Research Division, Schering-Plough Corporation, Bloomfield, USA, Paul M. Gross Chemical Laboratory, Duke University, Durham, USA, Department of Chemistry, Texas A&M University College Station, Texas, USA
Methods: 13C NMR, 1H NMR, EI-MS, IR, X-ray, acid hydrolysis, PD-MS, HPLC, UV, optical rotation measurement, CI-MS, FD-MS, derivatization
Found