Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales). The new compounds, distantly related to antibiotics of the kijanimicin class, are potent inhibitors of topical PMA-induced edema in the mouse ear assay when administered either topically or IP
lobophorins, antiinflammatory activity, Lobophora variegata
NCBI PubMed ID: 10450970Publication DOI: 10.1016/s0960-894x(99)00337-6Journal NLM ID: 9107377Publisher: Elsevier
Institutions: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, USA
Methods: 13C NMR, 1H NMR, methylation, NMR-2D, acid hydrolysis, biological assays, HPLC, extraction, acetylation, CC, cell growth, DEPT, HR-FAB-MS