With the continuing advancement of carbohydrate chemical synthesis, bacterial glycomes have become increasingly attractive and accessible synthetic targets. Although bacteria also produce carbohydrate-containing secondary metabolites, our review here will cover recent chemical synthetic efforts on bacterial surface glycans. The obtained compounds are excellent candidates for the development of improved structurally defined glycoconjugate vaccines to combat bacterial infections. They are also important probes for investigating glycan–protein interactions. Glycosylation strategies applied for the formation of some challenging glycosidic bonds of various uncommon sugars in a number of recently synthesized bacterial surface glycans are highlighted.
synthesis, carbohydrate, glycosyltransferase, glycoconjugate vaccine, Bacterial glycan
NCBI PubMed ID: 32920523Publication DOI: 10.1016/j.cbpa.2020.08.003Journal NLM ID: 9811312Publisher: London: Elsevier
Correspondence: Chen Xi
Institutions: Department of Chemistry, University of California Davis, Davis, CA, USA
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