Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Shigella dysenteriae [ICD11:
XN285 
]
Publication DOI: 10.1016/S0040-4020(01)88331-9Journal NLM ID: 2984170RPublisher: Pergamon Press
Institutions: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 U.S.A., Laboratory of Medicinal Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 U.S.A.
A glycosyl trichloroacetimidate derivative (1) of the tetrasaccharide α-d-Galp-(1→3)-α-d-GlcpNAc-(1→3)-α-L-Rhap-(1→3)-α-L-Rhap was synthesized in a highly stereoselective, stepwise manner, using methyl 1-thioglycosides of L-rhamnose, 2-azido-2-deoxy-D-glucose and D-galactose, as major intermediates. The protecting group scenario in compound 1 permits regioselective deblocking at its “non-reducing end” unit. Therefore 1 is a suitable intermediate for the preparation of extended fragments of the title polysaccharide.
Structure type: polymer chemical repeating unit
Location inside paper: A
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_125611,IEDB_130668,IEDB_130669,IEDB_136105,IEDB_136906,IEDB_137472,IEDB_137483,IEDB_141794,IEDB_141807,IEDB_151528,IEDB_151531,IEDB_190606,IEDB_225177,IEDB_885823,SB_7
Comments, role: fragment; published polymerization frame was shifted for conformity with other records.
Related record ID(s): 108636, 122424
NCBI Taxonomy refs (TaxIDs): 984897Reference(s) to other database(s): GTC:G76746EO, GlycomeDB:
6223
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There is only one chemically distinct structure:
Found 
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