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1. (Article ID: 1503)
 
D'Souza JM, Samuel GN, Reeves PR
Evolutionary origins and sequence of the Escherichia coli O4 O-antigen gene cluster
FEMS Microbiology Letters 244(1) (2005) 27-32
 

Escherichia coli express many types of O antigen, present in the outer membrane of the Gram-negative bacterial cell wall. O-Antigen biosynthesis genes are clustered together and differences seen in O-antigen types are due to genetic variation within this gene cluster. Sequencing of the E. coli O4 O-antigen gene cluster revealed a similar gene order and high levels of similarity to that of E. coli O26; indicating a common ancestor. These lateral transfer events observed within O-antigen gene clusters may occur as part of the evolution of the pathogenic clones.

biosynthesis, transfer, antigen, variation, O-antigen, Escherichia coli, gene cluster, cell wall, sequencing

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