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1. (Article ID: 1510)
 
Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves P, Xu J, Knirel YA, Wang L
Structural and genetic characterization of enterohaemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay
Journal of Bacteriology 187(2) (2005) 758-764
 

Comparison of the O antigens of Shigella boydii types 10 and 6 by chemical analysis and nuclear magnetic resonance spectroscopy showed that their structures are similar, with the only difference being the presence or absence of d-ribofuranose, which is the immunodominant sugar in S. boydii type 10. In S. boydii type 6, a residue previously reported as α-D-GlcpA, was shown to be β-D-GlcpA as in S. boydii type 10. S. boydii types 10 and 6 are reported not to cross-react serologically, and the role of d-ribofuranose in the specificity of S. boydii was confirmed by making a mutant of type 10 that lacked d-ribofuranose. However, S. boydii type 11, which has a d-ribofuranose but with different linkage does show cross-reaction with type 10. The O-antigen gene loci of S. boydii types 10 and 6 were shown to be virtually identical except that orf8 (wbaM), which was confirmed as the ribofuranosyltransferase gene, is interrupted by IS629 in type 6. Therefore, it is proposed that the O-antigen gene cluster of S. boydii type 6 was derived from type 10 by an IS element insertion.

genetic, synthesis, antigen, structure, gene, PCR, structural, characterization, O-antigen, O antigen, Escherichia, Escherichia coli, type, function, heteropolysaccharide, assay, transporter, development

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