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1. (Article ID: 1529)
 
Knirel YA, Lindner B, Vinogradov EV, Shaikhutdinova RZ, Senchenkova SN, Kocharova NA, Holst O, Pier GB, Anisimov AP
Cold temperature-induced modifications to the composition and structure of the lipopolysaccharide of Yersinia pestis
Carbohydrate Research 340(9) (2005) 1625-1630
 

Following a report of variations in the lipopolysaccharide (LPS) structure of Yersinia pestis at mammalian (37 degrees C) and flea (25 degrees C) temperatures, a number of changes to the LPS structure were observed when the bacterium was cultivated at a temperature of winter-hibernating rodents (6 degrees C). In addition to one of the known Y. pestis LPS types, LPS of a new type was isolated from Y. pestis KM218 grown at 6 degrees C. The core of the latter differs in: (i) replacement of terminal galactose with terminal d-glycero-d-manno-heptose; (ii) phosphorylation of terminal oct-2-ulosonic acid with phosphoethanolamine; (iii) a lower content of GlcNAc, and; (iv) the absence of glycine; lipid A differs in the lack of any 4-amino-4-deoxyarabinose and presumably partial (di)oxygenation of a fatty acid(s). The data obtained suggest that cold temperature switches on an alternative mechanism of control of the synthesis of Y. pestis LPS.

Lipopolysaccharide, structure, core, modification, agent, composition, Yersinia, PDF, communication, Yersinia pestis, Plague

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