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1. (Article ID: 1558)
 
Regue M, Izquierdo L, Fresno S, Pique N, Corsaro MM, Naldi T, De Castro C, Waidelich D, Merino S, Tomas JM
A second outer-core region in Klebsiella pneumoniae lipopolysaccharide
Journal of Bacteriology 187(12) (2005) 4198-4206
 

Up to now only one major type of core oligosaccharide has been found in the lipopolysaccharide of all Klebsiella pneumoniae strains analyzed. Applying a different screening approach, we identified a novel Klebsiella pneumoniae core (type 2). Both Klebsiella core types share the same inner core and the outer-core-proximal disaccharide, GlcN-(1,4)-GalA, but they differ in the GlcN substituents. In core type 2, the GlcpN residue is substituted at the O-4 position by the disaccharide β-Glcp(1-6)-α-Glcp(1, while in core type 1 the GlcpN residue is substituted at the O-6 position by either the disaccharide α-Hep?(1-4)-α-Kdo(2 or a Kdo residue (Kdo is 3-deoxy-D-manno-octulosonic acid). This difference correlates with the presence of a three-gene region in the corresponding core biosynthetic clusters. Engineering of both core types by interchanging this specific region allowed studying the effect on virulence. The replacement of Klebsiella core type 1 in a highly type 2 virulent strain (52145) induces lower virulence than core type 2 in a murine infection model.

Lipopolysaccharide, oligosaccharide, core, biosynthetic, strain, virulence, acid, Kdo, type, core oligosaccharide, infection, cluster, specific, Klebsiella, region, position, inner core, 3-deoxy-D-manno-octulosonic acid, difference, Klebsiella pneumoniae, disaccharide, engineering, effect, virulent, murine, approach, outer core region

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