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1. (Article ID: 1563)
 
Senchenkova SN, Feng L, Yang J, Shashkov AS, Cheng J, Liu D, Knirel YA, Reeves P, Jin Q, Ye Q, Wang L
Structural and genetic characterization of the Shigella boydii type 10 and 6 O antigens
Journal of Bacteriology 187(7) (2005) 2551-2554
 

Comparison of the O antigens of Shigella boydii types 10 and 6 by chemical analysis and nuclear magnetic resonance spectroscopy showed that their structures are similar, with the only difference being the presence or absence of d-ribofuranose, which is the immunodominant sugar in S. boydii type 10. In S. boydii type 6, a residue previously reported as α-D-GlcpA, was shown to be β-D-GlcpA as in S. boydii type 10. S. boydii types 10 and 6 are reported not to cross-react serologically, and the role of d-ribofuranose in the specificity of S. boydii was confirmed by making a mutant of type 10 that lacked d-ribofuranose. However, S. boydii type 11, which has a d-ribofuranose but with different linkage does show cross-reaction with type 10. The O-antigen gene loci of S. boydii types 10 and 6 were shown to be virtually identical except that orf8 (wbaM), which was confirmed as the ribofuranosyltransferase gene, is interrupted by IS629 in type 6. Therefore, it is proposed that the O-antigen gene cluster of S. boydii type 6 was derived from type 10 by an IS element insertion.

genetic, structure, gene, structural, characterization, O-antigen, O antigen, type, O antigens, O-antigens, Shigella, function, clone, Shigella boydii

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