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1. (Article ID: 1589)
 
Zych K, Perepelov AV, Siwinska M, Knirel YA, Sidorczyk Z
Structures of the O-polysaccharides and Classification of Proteus Genomospecies 4, 5 and 6 Into Respective Proteus Serogroups
FEBS Journal 272(21) (2005) 5536-5543
 

An acidic branched O-polysaccharide was isolated by mild acid degradation of the lipopolysaccharide (LPS) of Proteus genomospecies 4 and studied by sugar and methylation analyses along with 1H and 13C NMR spectroscopy, including 2D COSY, TOCSY, ROESY and H-detected 1H,13C HSQC experiments. The following structure of the pentasaccharide repeating unit of the O-polysaccharide was established, which is unique among Proteus polysaccharide structures: [see formula in text] where Qui3NAc stands for 3-acetamido-3,6-dideoxyglucose. Based on the O-polysaccharide structure and serological data, we propose classifying Proteus genomospecies 4 into a new, separate Proteus serogroup, O56. A weak cross-reactivity of Proteus genomospecies 4 antiserum with LPS of Providencia stuartii O18 and Proteus vulgaris OX2 was observed and is discussed in view of a similarity of the O-polysaccharide structures. Structural and serological investigations showed that Proteus genomospecies 5 and 6 should be classified into the existing Proteus serogroups O8 and O69, respectively.

O-antigen, Proteus, Proteus mirabilis, serological classification, 3-Acetamido-3, 6-dideoxy-d-glucose, O-serogroup

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