Some extracts from Inula viscosa were examined for acute antiinflammatory activity in vivo. Three flavonoids: rhamnocitrin (1), 7-O-methylaromadendrin (3), and 3-O-acetylpadmatin (4), a sesquiterpene lactone, inuviscolide (2), a sesquiterpene acid, ilicic acid (5), and a digalactosyl-diacylglycerol, inugalactolipid A (6), were isolated from the CH2Cl2 extract, identified by spectroscopic methods, and characterized as the topical antiinflammatory principles of this species. All these compounds proved to be effective against 12-O-tetradecanoylphorbol-13-acetate-induced ear edema in mice, although lacking activity against arachidonic acid-induced edema. In addition, compounds 5 and, markedly, 6 showed notable effects on a multiple-dose murine chronic dermatitis model. This is the first attempt to establish a rationale concerning the documented use of the plant on various skin diseases.
glycolipid, Inula viscosa, antiinflammatory constituent, inugalactolipid A
NCBI PubMed ID: 10217718Publication DOI: 10.1021/np980132uJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: Ríos JL
Institutions: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. V. Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain, Department of Pharmaceutical Sciences, University of Strathclyde, Strathclyde Institute for Biomedical Sciences Building, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK
Methods: 13C NMR, 1H NMR, statistical analysis, DEPT, anti-inflammation assay, alkaline methanolysis, HRGC
Found