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Structure type: monomer ; 515.2172 [M]+
C₂₇H₃₃NO₉
Trivial name: actinoflavoside B
Compound class: flavonoid glycoside

• Article ID: 6247
  Jeong H, Jo SJ, Bae M, Kim YR, Moon K "Actinoflavosides B-D, Flavonoid Type Glycosides from Tidal Mudflat-Derived Actinomyces" - Marine Drugs 20(9) (2022) 565
  

  Three new secondary metabolites, actinoflavosides B-D (1-3), were discovered in the culture broth of two actinomycete strains (JML48 and JMS33) that were isolated from tidal mudflat sediment in Muan, Republic of Korea. The planar structures of the actinoflavosides were elucidated by MS, UV, and NMR analyses. The stereochemistry of an aminosugar, 2,3,6-trideoxy-3-amino-ribopyranoside in the actinoflavosides was determined by J-based configuration analysis using values obtained from DQF-COSY experiments and modified Mosher's method. Actinoflavosides B-D (1-3) displayed antibacterial activity against Pseudomonas aeruginosa, and actinoflavoside D (3) significantly increased IL-2 production in mouse splenocytes.

  structural determination, antibacterial, flavonoid, actinoflavoside, immune modulator, secondary metabolite, tidal mudflat

  NCBI PubMed ID: 36135754
  Publication DOI: 10.3390/md20090565
  Journal NLM ID: 101213729
  Publisher: Basel, Switzerland: Molecular Diversity Preservation International
  Correspondence: Y.R. Kim ; K. Moon
  Institutions: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University, Gwangju 61186, Korea, College of Pharmacy, Gachon University, Incheon 21936, Korea
  Methods: 13C NMR, 1H NMR, NMR-2D, chemical analysis, ELISA, FTIR, HPLC, UV, LC-MS, HR-TOF-MS
  
   
  
  Streptomyces sp. CNB-689, Streptomyces sp. JML48, Streptomyces sp. JMS33
  CSDB ID 8479 (all data & tools)

Show legend Show as text

Structure type: monomer ; 457.1735 [M]+
C₂₄H₂₇NO₈
Trivial name: actinoflavoside C
Compound class: flavonoid glycoside

• Article ID: 6247
  Jeong H, Jo SJ, Bae M, Kim YR, Moon K "Actinoflavosides B-D, Flavonoid Type Glycosides from Tidal Mudflat-Derived Actinomyces" - Marine Drugs 20(9) (2022) 565
  

  Three new secondary metabolites, actinoflavosides B-D (1-3), were discovered in the culture broth of two actinomycete strains (JML48 and JMS33) that were isolated from tidal mudflat sediment in Muan, Republic of Korea. The planar structures of the actinoflavosides were elucidated by MS, UV, and NMR analyses. The stereochemistry of an aminosugar, 2,3,6-trideoxy-3-amino-ribopyranoside in the actinoflavosides was determined by J-based configuration analysis using values obtained from DQF-COSY experiments and modified Mosher's method. Actinoflavosides B-D (1-3) displayed antibacterial activity against Pseudomonas aeruginosa, and actinoflavoside D (3) significantly increased IL-2 production in mouse splenocytes.

  structural determination, antibacterial, flavonoid, actinoflavoside, immune modulator, secondary metabolite, tidal mudflat

  NCBI PubMed ID: 36135754
  Publication DOI: 10.3390/md20090565
  Journal NLM ID: 101213729
  Publisher: Basel, Switzerland: Molecular Diversity Preservation International
  Correspondence: Y.R. Kim ; K. Moon
  Institutions: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University, Gwangju 61186, Korea, College of Pharmacy, Gachon University, Incheon 21936, Korea
  Methods: 13C NMR, 1H NMR, NMR-2D, chemical analysis, ELISA, FTIR, HPLC, UV, LC-MS, HR-TOF-MS
  
   
  
  Streptomyces sp. CNB-689, Streptomyces sp. JML48, Streptomyces sp. JMS33
  CSDB ID 21009 (all data & tools)