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Structure type: polymer chemical repeating unit
Compound class: EPS
Contained glycoepitopes: IEDB_115576,IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141111,IEDB_141793,IEDB_141795,IEDB_141830,IEDB_141834,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_153220,IEDB_153756,IEDB_164174,IEDB_164175,IEDB_164176,IEDB_164480,IEDB_174840,IEDB_241100,IEDB_76933,IEDB_983930,SB_136,SB_196,SB_197,SB_198,SB_44,SB_67,SB_72,SB_73

• Article ID: 6297
  Qi M, Zheng C, Wu W, Yu G, Wang P "Exopolysaccharides from Marine Microbes: Source, Structure and Application" - Marine Drugs 20(8) (2022) 512
  

  The unique living environment of marine microorganisms endows them with the potential to produce novel chemical compounds with various biological activities. Among them, the exopolysaccharides produced by marine microbes are an important factor for them to survive in these extreme environments. Up to now, exopolysaccharides from marine microbes, especially from extremophiles, have attracted more and more attention due to their structural complexity, biodegradability, biological activities, and biocompatibility. With the development of culture and separation methods, an increasing number of novel exopolysaccharides are being found and investigated. Here, the source, structure and biological activities of exopolysaccharides, as well as their potential applications in environmental restoration fields of the last decade are summarized, indicating the commercial potential of these versatile EPS in different areas, such as food, cosmetic, and biomedical industries, and also in environmental remediation.

  structure, exopolysaccharides, EPS, marine microorganisms, biological activities, environmentalremediation

  NCBI PubMed ID: 36005515
  Publication DOI: 10.3390/md20080512
  Journal NLM ID: 101213729
  Publisher: Basel, Switzerland: Molecular Diversity Preservation International
  Correspondence: W. Wu ; G. Yu ; P. Wang
  Institutions: College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China, Key Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
  
   
  
  Hansfordia sinuosae
  CSDB ID 21132 (all data & tools)

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Structure type: polymer chemical repeating unit ; 22500
Compound class: mannan, EPC
Contained glycoepitopes: IEDB_130701,IEDB_134620,IEDB_136104,IEDB_140116,IEDB_141111,IEDB_141793,IEDB_141795,IEDB_141830,IEDB_141834,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_153220,IEDB_153756,IEDB_164174,IEDB_164175,IEDB_164176,IEDB_164480,IEDB_174840,IEDB_241100,IEDB_76933,IEDB_983930,SB_136,SB_196,SB_197,SB_198,SB_44,SB_67,SB_72

• Article ID: 8615
  Li H, Cao K, Cong P, Liu Y, Cui H, Xue C "Structure characterization and antitumor activity of the extracellular polysaccharide from the marine fungus Hansfordia Sinuosae" - Carbohydrate Polymers 190 (2018) 87-94
  

  A neutral water soluble polysaccharide (HPA) was isolated from the marine fungus Hansfordia sinuosae. Monosaccharide composition analysis indicated that HPA was mainly composed of mannose with minor amounts of galactose and glucose. The molecular weight of HPA was approximately 22.5 kDa as analyzed by HPGPC. Structure analysis of HPA with methylation and 1D, 2D NMR indicated that HPA was composed of [α-D-Manp(1→], [→2)-α-D-Manp(1→], [→3)-α-D-Manp(1→] and [→2,6)-α-D-Manp(1→] with [α-D-Manp(1→] linked to C-6 position of [→2,6)-α-D-Manp(1→]. The antitumor effect of HPA was evaluated in vitro. HPA showed remarkable inhibitory effect on human cervical carcinoma HeLa cells and human breast carcinoma MCF-7 cells. When cells were incubated with HPA at 400 μg/mL for 48 h, the inhibition rate on HeLa and MCF-7 cells was 79.5% and 73.8%, respectively. Furthermore, for HeLa cells, HPA could increase intracellular ROS levels, induce cells apoptosis, decrease mitochondrial membrane potential, and elevate the expression of caspase-3. The results suggested that HPA could be explored as a potential antitumor agent.

  structure, extracellular polysaccharide, apoptosis, antitumor activity, Hansfordia sinuosae

  NCBI PubMed ID: 29628263
  Publication DOI: 10.1016/j.carbpol.2018.02.077
  Journal NLM ID: 8307156
  Publisher: Elsevier
  Correspondence: Li H ; Xue C
  Institutions: College of Food Science and Engineering, Ocean University of China, Qingdao, China
  Methods: 13C NMR, 1H NMR, GC-MS, ROESY, TOCSY, methylation analysis, dialysis, anticancer activity assay, HPGPC, phenol-sulfuric acid assay, HMBC, carbazole-sulfuric acid assay, ethanol precipitation, HMQC, COSY, TFA hydrolysis
  
   
  
  Hansfordia sinuosae
  CSDB ID 48884 (all data & tools)