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Two new diterpenic glycosides, virescenosides M (1) and N (2), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures were determined on the basis of MS and NMR data as β-D-altropyranosido-19-7-oxo-isopimara-8,15-diene-2α,3β-diol (1) and β-D-altropyranosido-19-isopimara-7,15-diene-2α,3β,6β-triol (2). Three other altrosides (3−5), identified as virescenosides A, B, and C from the terrestrial strain Acremonium luzulae, were also isolated. The cytotoxic activity of the virescenosides was examined.

Publication DOI: 10.1021/np9904004
Journal NLM ID: 7906882
Publisher: American Society of Pharmacognosy
Correspondence: piboc@stl.ru
Institutions: Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok 22, Russian Federation
Methods: 13C NMR, 1H NMR, EI-MS, acid hydrolysis, biological assays, HPLC, UV, CD, HR-MALDI-MS

Meroterpenoids, including several biologically active metabolites from marine microorganisms mainly fungi and actinomycete bacteria, represent promising structural scaffolds with not only diverse biological activities such as antimicrotubule, cytotoxic and antiproliferative but also different mechanisms of action. In this chapter, an overview on structural diversity and anticancer activity of mixed biogenesis terpenoid derivatives (meroterpenoids) from marine microorganisms is presented with highlight on individual examples of the most promising candidates in cancer chemotherapy and prevention

cytotoxicity, Marine bacteria, marine microorganisms, anticancer activities, marine-derived fungi, marine-derived actinomycetes, meroterpenoids, terpenyl alkaloids, terpenyl glycosides, terpenyl polyketides

Publication DOI: 10.1007/978-3-319-07145-9_16
Publisher: Cham: Springer
Correspondence: ankijjoa@icbas.up.pt
Editors: Kim S-K
Institutions: ICBAS—Instituto de Ciências Biomédicas Abel Salazar and Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Porto, Portugal

Background: Natural products acquire vast and intriguing structural diversity and have been recognized as a tremendously diverse source of new lead compounds. Numerous bioactive secondary metabolites are present in the form of glycosylated molecules in which the sugar parts are normally associated with the interaction along with molecular recognition of the cellular target. Scope and approach: The presence of sugar entities are crucial as well as in some cases necessary, for therapeutic effects. Establishing novel and potent glycosylated secondary metabolites has formed a main goal in the natural product field from fungi and bacteria. These compounds possess a diverse range of sugar units. Key findings and conclusions: Fungi is considered one of the important sources for approved drugs with a diverse range of mode of action. The sugar part in numerous pharmacologically active natural products enhances bioavailability, biological potential, reduce toxicity, and improve stability. The vast majority of glyocosides showed antimicrobial effects, cytotoxic, antiviral and antiinflammatory effects. Notably, numerous fungal glycosides presented in this review illustrate significant antimicrobial effects towards various microorganisms especially against plant pathogens. The antimicrobial effects of these fungal glycosides indicate that these metabolites could be employed as natural preservatives in food in order to abolish or control the growth of pathogenic and spoilage microorganisms.

glycoside, antimicrobial, fungi, food preservative, secondary metabolites

Publication DOI: 10.1016/j.tifs.2021.02.029
Journal NLM ID: 9426004
Publisher: Cambridge, UK: Elsevier Trends Journals
Correspondence: Hussain H ; Hussain H ; Xiao J ; Xiao J
Institutions: Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany, Institute of the Chemistry of Plant Substances of the Academy Sciences of Uzbekistan, Tashkent, Uzbekistan, School of Pharmaceutical Sciences and Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China, Department Materials Engineering, National University of Sciences and Technology (NUST) H12, Islamabad, Pakistan, Department of Chemistry and Polymer Science, University of Stellenbosch, Matieland, South Africa, Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, China, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Food Science and Technology, University of Vigo - Ourense Campus, Ourense, Spain

A diverse array of secondary metabolites have been isolated and characterized from marine-derived fungi. The structures and biological activities of these metabolites are presented. Additionally, some basic principles of mycology are covered. Overall, 273 structures are presented and the review contains 162 references

biological activity, cytotoxicity, metabolites, marine-derived fungi

NCBI PubMed ID: 15039840
Publication DOI: 10.1039/b301926h
Journal NLM ID: 8502408
Publisher: London: Royal Society of Chemistry
Correspondence: cireland@pharm.utah.edu
Institutions: Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, USA

Terpenes from marine-derived fungi show a pronounced degree of structural diversity, and due to their interesting biological and pharmacological properties many of them have aroused interest from synthetic chemists and the pharmaceutical industry alike. The aim of this paper is to give an overview of the structural diversity of terpenes from marine-derived fungi, highlighting individual examples of chemical structures and placing them in a context of other terpenes of fungal origin. Wherever possible, information regarding the biological activity is presented

biological activity, marine-derived fungi, natural products chemistry, terpenes

NCBI PubMed ID: 20948911
Publication DOI: 10.3390/md8082340
Journal NLM ID: 101213729
Publisher: Basel, Switzerland: Molecular Diversity Preservation International
Correspondence: r.ebel@abdn.ac.uk
Institutions: Marine Biodiscovery Centre, University of Aberdeen, Aberdeen, UK