Two antifungal triterpenoid glycosides, hyalodendrosides A and B (1 and 2), were isolated from a solid matrix fermentation of a lignicolous hyphomycete, Hyalodendron sp. Their structures were determined based upon extensive examination of spectral parameters, particularly NMR and MS data. Both compounds have β-linked glucose moieties. Compounds 1 and 2 show weak to moderate antifungal activity against some clinically relevant fungi.
Publication DOI: 10.1021/np9903898Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: gerald_bills@merck.com
Institutions: Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065
Methods: 13C NMR, 1H NMR, ESI-MS, biological assays, HPLC, ROESY, HMBC, HMQC, COSY, NOESY, HR-FAB-MS
Found