Chemical studies of an organic extract from solid-substrate fermentations of the mycoparasitic fungus Humicola fuscoatra NRRL 22980, originally isolated as a colonist of Aspergillus flavus sclerotia, afforded two new unrelated compounds that we have named fuscoatroside (1) and fuscoatramide (2). The structures of these metabolites were elucidated by analysis of NMR and MS data. Fuscoatroside (1) is a triterpenoid glycoside that exhibited activity in antifungal assays against A. flavus. This extract also contained the known metabolites 7-deoxysterigmatocystin, sterigmatocystin, isosclerone, and decarestrictines A1 and I.
Publication DOI: 10.1021/np020295pJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: James Gloer
Institutions: Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, Bioactive Agents Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, United States Department of Agriculture, Peoria, Illinois 61604
Methods: 13C NMR, 1H NMR, gel filtration, acid hydrolysis, HPLC, biological assay, HMBC, NOESY, HR-FAB-MS
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