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References to other databases: Chemspider:8779234
Structural formula & atomic coordinates
Sweet-II 3D model
Show glycosyltransferases

Three new compounds, (24R,S)-3α-acetoxy-24-hydroxy-5α-lanosta-8,25-dien-21-oic acid, named tsugaric acid C (1); 3α-acetoxy-5α-lanosta-8,24-diene-21-O-β-D-xyloside, named tsugarioside B (2); and 3α-acetoxy-(Z)-24-methyl-5α-lanosta-8,23,25-trien-21-oic acid ester β-D-xyloside, named tsugarioside C (3), and a mixture of two known steroids were isolated from the fruit bodies of Ganoderma tsugae. The structures of 1−3 were determined by spectral and chemical methods. The cytotoxic activity of the lanostanoid constituents of this fungus was evaluated against several different cancer cell lines.

Publication DOI: 10.1021/np990367l
Journal NLM ID: 7906882
Publisher: American Society of Pharmacognosy
Correspondence: lincna@cc.kmu.edu.tw
Institutions: School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China, Department of Microbiology, Medical College, National Cheng Kung University, Tainan, Taiwan 701, Republic of China
Methods: 13C NMR, 1H NMR, IR, FAB-MS, optical rotation, LiAlH4 reduction, tumor cell growth inhibition sssays

So far, more than 20 species of Ganoderma (Lingzhi) fungi have been studied, including G. lucidum, G. sinense, G. japonicum, G. capense, G. australe, G. tsugae, G. applanatum, G. tropicus, G. boniense, G. duropora, G. resinaceum, G. theaecolum, G. cochlear, G. atrum, G. formosanum, G. boninense, G. colossum, G. concinna, G. amboinense, G. pfeifferi, and G. orbiforme. Over 600 compounds were isolated and identified from the genus Ganoderma. The components in Ganoderma contained triterpenes, meroterpenoids, steroids, alkaloids, nucleosides, nucleobases, and polysaccharides, in which triterpenes were the main compounds, and more than 300 triterpenes obtained from it. With the use of new technology of separation and purification, the other types of compounds, such as meroterpenoids, alkaloids, nucleosides, and polysaccharides were reported in recent years. Herein, the structural classifications and characteristics and separation methods were summarized.

polysaccharides, meroterpenoids, steroids, Ganoderma, triterpenes, alkaloids and nucleosides

NCBI PubMed ID: 31677140
Publication DOI: 10.1007/978-981-13-9867-4_3
Publisher: Singapore: Springer
Correspondence: rych@imm.ac.cn
Editors: Lin Z, Yang B
Institutions: Department of Natural Product Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China