Three new compounds, (24R,S)-3α-acetoxy-24-hydroxy-5α-lanosta-8,25-dien-21-oic acid, named tsugaric acid C (1); 3α-acetoxy-5α-lanosta-8,24-diene-21-O-β-D-xyloside, named tsugarioside B (2); and 3α-acetoxy-(Z)-24-methyl-5α-lanosta-8,23,25-trien-21-oic acid ester β-D-xyloside, named tsugarioside C (3), and a mixture of two known steroids were isolated from the fruit bodies of Ganoderma tsugae. The structures of 1−3 were determined by spectral and chemical methods. The cytotoxic activity of the lanostanoid constituents of this fungus was evaluated against several different cancer cell lines.
Publication DOI: 10.1021/np990367lJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: lincna@cc.kmu.edu.tw
Institutions: School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China, Department of Microbiology, Medical College, National Cheng Kung University, Tainan, Taiwan 701, Republic of China
Methods: 13C NMR, 1H NMR, IR, FAB-MS, optical rotation, LiAlH4 reduction, tumor cell growth inhibition sssays
Found