Found 1 structure.
Displayed structure 1
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1. Compound ID: 17809
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/Variants 0/-+
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EtN-(1--P--2)--+ |
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EtN-(1--P--?)--+ | |
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Subst-(?-?)-EtN-(1--P--6)--+ | | |
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a-D-Man-(1-3)-+ | | | Pam-(1-2)-+ |
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a-D-Man-(1-2)-a-D-Man-(1-2)-a-D-Man-(1-2)-a-D-Man-(1-6)-a-D-Man-(1-4)-a-D-GlcN-(1-6)-INO-(1--P--1)--Gro
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Crt-(1-2)-+
/Variants 0/ is:
Pam-(1-3)-
OR (exclusively)
Myr-(1-3)-
Subst = protein |
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Structure type: oligomer
Trivial name: glycosylphosphatidylinositol (GPI) anchor
Compound class: glycophospholipid
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141111,IEDB_141181,IEDB_141793,IEDB_141795,IEDB_141807,IEDB_141829,IEDB_141830,IEDB_141832,IEDB_141833,IEDB_143632,IEDB_144983,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_158638,IEDB_164174,IEDB_164175,IEDB_164176,IEDB_164480,IEDB_174840,IEDB_176772,IEDB_474450,IEDB_76933,IEDB_983930,SB_136,SB_191,SB_196,SB_197,SB_198,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 6960
Pittet M1, Conzelmann A "Biosynthesis and function of GPI proteins in the yeast Saccharomyces cerevisiae" -
Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids 1771(3) (2007) 405-420
Like most other eukaryotes, Saccharomyces cerevisiae harbors a GPI anchoring machinery and uses it to attach proteins to membranes. While a few GPI proteins reside permanently at the plasma membrane, a majority of them gets further processed and is integrated into the cell wall by a covalent attachment to cell wall glucans. The GPI biosynthetic pathway is necessary for growth and survival of yeast cells. The GPI lipids are synthesized in the ER and added onto proteins by a pathway comprising 12 steps, carried out by 23 gene products, 19 of which are essential. Some of the estimated 60 GPI proteins predicted from the genome sequence serve enzymatic functions required for the biosynthesis and the continuous shape adaptations of the cell wall, others seem to be structural elements of the cell wall and yet others mediate cell adhesion. Because of its genetic tractability S. cerevisiae is an attractive model organism not only for studying GPI biosynthesis in general, but equally for investigating the intracellular transport of GPI proteins and the peculiar role of GPI anchoring in the elaboration of fungal cell walls.
biosynthesis, cell wall, ceramide, Glycosylphosphatidylinositol, Saccharomyces cerevisiae, Lipid remodeling
NCBI PubMed ID: 16859984Publication DOI: 10.1016/j.bbalip.2006.05.015Journal NLM ID: 0217513Publisher: Elsevier
Correspondence: andreas.conzelmann@unifr.ch (Andreas Conzelmann)
Institutions: Department of Medicine, Division of Biochemistry, Fribourg, Switzerland
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