Four new triterpenoid glycosides, kolokosides A-D (1-4), along with the known compound 19,20-epoxycytochalasin N, were isolated from cultures of a Hawaiian wood-decay fungus (Xylaria sp.). The structures and relative configurations of 1-4 were determined primarily by analysis of NMR data, and the absolute configuration of 1 was assigned by application of the exciton chirality method. Compound 1 exhibited activity against Gram-positive bacteria.
fungus, fungicolous isolate, fernane
Publication DOI: 10.1021/np060546kJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: James Gloer
Institutions: Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Mycotoxin Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, USDA, Peoria, Illinois, USA
Methods: 13C NMR, 1H NMR, GC-MS, acid hydrolysis, composition analysis, HPLC, extraction, optical rotation measurement, HR-ESI-MS, DEPT
Found