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Structure type: oligomer
Trivial name: α-(1-3)-mannobiose
Compound class: disaccharide
Contained glycoepitopes: IEDB_130701,IEDB_137485,IEDB_144983,IEDB_152206,IEDB_164174,IEDB_983930,SB_197,SB_44,SB_67,SB_72

• Article ID: 7240
  Bouveng HO, Fraser RN, Lindberg B "Polysaccharides elaborated by Armillaria mellea(tricholomataceae). Part II. Water-soluble mycelium polysaccharides" - Carbohydrate Research 4(1) (1967) 20-31
  

  Cultures of Armillaria mellea, with D-glucitol as the carbon source, have been examined for content of water-soluble polysaccharide. Of the complex mixture obtained, two components have been isolated and structurally examined. The first has been shown to be a xylomannan having a backbone of α(1→3)-linked D-mannopyranose residues, every second to third of which is substituted in the 4-position by a 4-O-α-D-xylopyranosyl-D-xylopyranose residue. The second polysaccharide contains D-galactose, D-mannose, L-fucose, and 3-O-methyl-D-galactose, in a molecular ratio of 6:1:2:2. Structural features include a main chain of α-(1→6)-linked D-galactopyranose residues, substituted in the 2-position by single L-fucopyranose residues or by 3-O-α-D-mannopyranosyl-L-fucopyranose and 6-O-(3-O-methyl-α-D-galactopyranosyl)-D-galactose residues.

  structure, polysaccharide, Armillaria mellea

  Publication DOI: 10.1016/S0008-6215(00)81144-1
  Journal NLM ID: 0043535
  Publisher: Elsevier
  Institutions: Träkemiska avdelningen, Svenska Träforskningsinstitutet and Institutionen för Organisk Kemi, Stockholm Universitet, Stockholm, Sweden
  Methods: methylation, TLC, acid hydrolysis, paper chromatography, methanolysis, electrophoresis, enzymatic digestion, ion-exchange chromatography, extraction, periodate oxidation, optical rotation measurement, reduction, column chromatography, ultrasonication
  
   
  
  Armillaria mellea
  CSDB ID 43900 (all data & tools)
• Article ID: 7654
  Shibata N, Kobayashi H, Suzuki S "Immunochemistry of pathogenic yeast, Candida species, focusing on mannan" - Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 88(6) (2012) 250-265
  

  This review describes recent findings based on structural and immunochemical analyses of the cell wall mannan of Candida albicans, and other medically important Candida species. Mannan has been shown to consist of α-1,2-, α-1,3-, α-1,6-, and β-1,2-linked mannopyranose units with few phosphate groups. Each Candida species has a unique mannan structure biosynthesized by sequential collaboration between species-specific mannosyltransferases. In particular, the β-1,2-linked mannose units have been shown to comprise a characteristic oligomannosyl side chain that is strongly antigenic. For these pathogenic Candida species, cell-surface mannan was also found to participate in the adhesion to the epithelial cells, recognition by innate immune receptors and development of pathogenicity. Therefore, clarification of the precise chemical structure of Candida mannan is indispensable for understanding the mechanism of pathogenicity, and for development of new antifungal drugs and immunotherapeutic procedures.

  pathogenicity, mannan, 1H NMR, Candida, Mannosyltransferase, Dectin-2

  NCBI PubMed ID: 22728440
  Publication DOI: 10.2183/pjab.88.250
  Journal NLM ID: 9318162
  Publisher: Japan Academy
  Correspondence: suzusige@seagreen.ocn.ne.jp
  Institutions: Sendai Research Institute for Mycology, Miyagi, Japan, Department of Infection and Host Defense, Tohoku Pharmaceutical University, Miyagi, Japan, Department of Microbiology, Nagasaki International University, Nagasaki, Japan, Tohoku Pharmaceutical University, Miyagi, Japan
  
   
  
  Saccharomyces cerevisiae
  CSDB ID 45766 (all data & tools)