In order to search for structurally novel and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment collected in the Hongdao sea salt field. From the ethyl acetate extract of Alternaria raphani, three new cerebrosides, alternarosides A-C (1-3), and a new diketopiperazine alkaloid, alternarosin A (4), together with 15 known compounds were isolated and identified by spectroscopic and chemical methods, as well as X-ray crystal diffraction analysis. Compounds 1-4 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Candida albicans with MIC values ranging from 70 to 400 muM.
cerebroside
NCBI PubMed ID: 19685913Publication DOI: 10.1021/np9002299Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: weimingzhu@ouc.edu.cn
Institutions: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
Methods: 13C NMR, 1H NMR, NMR-2D, ESI-MS/MS, NMR-1D, methanolysis, extraction, optical rotation measurement, CC, HR-ESI-MS
Found