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Structure type: monomer ; 818.5565 [M+Na]+
C₄₁H₈₁NO₁₃
Compound class: glycosphingolipid, cerebroside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 7233
  Qi JH, Ojika M, Sakagami Y "Neuritogenic cerebrosides from an edible Chinese mushroom. Part 2: Structures of two additional termitomycesphins and activity enhancement of an inactive cerebroside by hydroxylation" - Bioorganic and Medicinal Chemistry 9(8) (2001) 2171-2177
  

  Termitomycesphins E and F, novel cerebrosides that are hydroxylated around the middle of the long-chain base (LCB), have been isolated from the edible Chinese mushroom Termitomyces albuminosus (Berk.) Heim. ('Jizong' in Chinese) together with termitomycesphins A-D, and shown to induce neuronal differentiation in rat PC12 cells. Their stereostructures have been determined based on their chemical derivatization and spectroscopic analysis. The major cerebroside obtained from the same mushroom was not hydroxylated around the middle of the LCB and was inactive against PC12 cells, suggesting the importance of the extra hydroxyl group on LCB. The Di- and tetrahydroxylation of this inactive cerebroside resulted in the enhancement of its neuritogenic activity.

  cerebroside

  NCBI PubMed ID: 11504654
  Publication DOI: 10.1016/S0968-0896(01)00125-0
  Journal NLM ID: 9413298
  Publisher: Elsevier
  Correspondence: ojika@agr.nagoya-u.ac.jp
  Institutions: Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, TLC, ESI-MS/MS, NMR-1D, methanolysis, UV, extraction, optical rotation measurement, CC, HR-ESI-MS, bioassay, optical rotation
  
   
  
  Termitomyces albuminosus
  CSDB ID 42267 (all data & tools)

Show legend Show as text

Structure type: monomer ; 1106.6967 [M+Na]
C₅₈H₁₀₁NO₁₇
Compound class: glycosphingolipid, cerebroside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192,SB_61

• Article ID: 7233
  Qi JH, Ojika M, Sakagami Y "Neuritogenic cerebrosides from an edible Chinese mushroom. Part 2: Structures of two additional termitomycesphins and activity enhancement of an inactive cerebroside by hydroxylation" - Bioorganic and Medicinal Chemistry 9(8) (2001) 2171-2177
  

  Termitomycesphins E and F, novel cerebrosides that are hydroxylated around the middle of the long-chain base (LCB), have been isolated from the edible Chinese mushroom Termitomyces albuminosus (Berk.) Heim. ('Jizong' in Chinese) together with termitomycesphins A-D, and shown to induce neuronal differentiation in rat PC12 cells. Their stereostructures have been determined based on their chemical derivatization and spectroscopic analysis. The major cerebroside obtained from the same mushroom was not hydroxylated around the middle of the LCB and was inactive against PC12 cells, suggesting the importance of the extra hydroxyl group on LCB. The Di- and tetrahydroxylation of this inactive cerebroside resulted in the enhancement of its neuritogenic activity.

  cerebroside

  NCBI PubMed ID: 11504654
  Publication DOI: 10.1016/S0968-0896(01)00125-0
  Journal NLM ID: 9413298
  Publisher: Elsevier
  Correspondence: ojika@agr.nagoya-u.ac.jp
  Institutions: Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, TLC, ESI-MS/MS, NMR-1D, methanolysis, UV, extraction, optical rotation measurement, CC, HR-ESI-MS, bioassay, optical rotation
  
   
  
  Termitomyces albuminosus
  CSDB ID 42269 (all data & tools)